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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FOXO3 All Species: 13.33
Human Site: S442 Identified Species: 29.33
UniProt: O43524 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43524 NP_001446.1 673 71277 S442 F G P S S L N S L R Q S P M Q
Chimpanzee Pan troglodytes XP_522749 829 87557 Q596 N S P S P N Y Q K Y T Y G Q S
Rhesus Macaque Macaca mulatta XP_001093593 672 71242 S441 F G P S S L N S L R Q S P M Q
Dog Lupus familis XP_539075 494 52999 L264 G P S S L N S L R Q S P M Q T
Cat Felis silvestris
Mouse Mus musculus Q9R1E0 652 69484 T422 S P N Y S K Y T Y G Q S S M S
Rat Rattus norvegicus NP_001099865 672 71179 S441 F G P A S L N S L R Q S P M Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511165 628 67175 E398 S P M Q T I Q E N K P A T F S
Chicken Gallus gallus Q90964 451 48838 P221 G N Y W M L D P S S D D V F I
Frog Xenopus laevis Q6EUW1 657 70366 S427 S F N F P L T S L R Q S P M Q
Zebra Danio Brachydanio rerio NP_571160 651 69843 L421 F G P S P G S L R Q K P M Q T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95V55 613 67394 H382 S L N C S C M H N A R D G L S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40 99.5 71 N.A. 45 94.5 N.A. 67.4 22.2 70.7 58.9 N.A. 29.5 N.A. N.A. N.A.
Protein Similarity: 100 52.4 99.6 72.3 N.A. 61 96.5 N.A. 74.7 34.4 80.8 71.7 N.A. 42.6 N.A. N.A. N.A.
P-Site Identity: 100 13.3 100 6.6 N.A. 26.6 93.3 N.A. 0 6.6 60 26.6 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 13.3 100 20 N.A. 33.3 100 N.A. 26.6 13.3 60 46.6 N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 0 0 0 0 0 10 0 10 0 0 0 % A
% Cys: 0 0 0 10 0 10 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 10 0 0 0 10 19 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % E
% Phe: 37 10 0 10 0 0 0 0 0 0 0 0 0 19 0 % F
% Gly: 19 37 0 0 0 10 0 0 0 10 0 0 19 0 0 % G
% His: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 10 % I
% Lys: 0 0 0 0 0 10 0 0 10 10 10 0 0 0 0 % K
% Leu: 0 10 0 0 10 46 0 19 37 0 0 0 0 10 0 % L
% Met: 0 0 10 0 10 0 10 0 0 0 0 0 19 46 0 % M
% Asn: 10 10 28 0 0 19 28 0 19 0 0 0 0 0 0 % N
% Pro: 0 28 46 0 28 0 0 10 0 0 10 19 37 0 0 % P
% Gln: 0 0 0 10 0 0 10 10 0 19 46 0 0 28 37 % Q
% Arg: 0 0 0 0 0 0 0 0 19 37 10 0 0 0 0 % R
% Ser: 37 10 10 46 46 0 19 37 10 10 10 46 10 0 37 % S
% Thr: 0 0 0 0 10 0 10 10 0 0 10 0 10 0 19 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % V
% Trp: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 10 0 0 19 0 10 10 0 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _